Retinal lesions in rats after treatment with chlorphentermine or with tricyclic antidepressants
Identifieur interne : 003A55 ( Main/Exploration ); précédent : 003A54; suivant : 003A56Retinal lesions in rats after treatment with chlorphentermine or with tricyclic antidepressants
Auteurs : Renate Lüllmann-Rauch [Allemagne]Source :
- Virchows Archiv B [ 0340-6075 ] ; 1974-12-01.
English descriptors
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Abstract
Summary: Treatment of rats with the anorectic drug chlorphentermine or with the tricyclic antidepressants iprindole, 1-chlor-amitriptyline, clomipramine and imipramine induced cellular lesions in retinal pigment epithelial cells and in retinal ganglion cells. The ultrastructural findings, which are characterized by the formation of numerous membrane-bound cytoplasmic inclusions with crystalloid or lamellar internal patterns, are interpreted as a manifestation of a drug-induced phospholipidosis.
Url:
DOI: 10.1007/BF02889346
Affiliations:
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